Discovery of Dual ETA/ETB Receptor Antagonists from Traditional Chinese Herbs through in Silico and in Vitro Screening

Endothelin-1 receptors (ETAR and ETBR) act as a pivotal regulator in the biological effects of ET-1 and represent a potential drug target for the treatment of multiple cardiovascular diseases. The purpose of the study is to discover dual ETA/ETB receptor antagonists from traditional Chinese herbs. L...

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Detalles Bibliográficos
Autores principales: Wang, Xing, Zhang, Yuxin, Liu, Qing, Ai, Zhixin, Zhang, Yanling, Xiang, Yuhong, Qiao, Yanjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813245/
https://www.ncbi.nlm.nih.gov/pubmed/26999111
http://dx.doi.org/10.3390/ijms17030389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813245/
https://www.ncbi.nlm.nih.gov/pubmed/26999111
http://dx.doi.org/10.3390/ijms17030389

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