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Nuclear envelope expansion is crucial for proper chromosomal segregation during a closed mitosis
Here, we screened a 10,371 library of diverse molecules using a drug-sensitive fission yeast strain to identify compounds which cause defects in chromosome segregation during mitosis. We identified a phosphorium-ylide-based compound Cutin-1 which inhibits nuclear envelope expansion and nuclear elong...
Autores principales: | Takemoto, Ai, Kawashima, Shigehiro A., Li, Juan-Juan, Jeffery, Linda, Yamatsugu, Kenzo, Elemento, Olivier, Nurse, Paul |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813296/ https://www.ncbi.nlm.nih.gov/pubmed/26869222 http://dx.doi.org/10.1242/jcs.181560 |
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