KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation

KMT2D, which encodes a histone H3K4 methyltransferase, has been implicated in human congenital heart disease in the context of Kabuki syndrome. However, its role in heart development is not understood. Here, we demonstrate a requirement for KMT2D in cardiac precursors and cardiomyocytes during cardi...

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Detalles Bibliográficos
Autores principales: Ang, Siang-Yun, Uebersohn, Alec, Spencer, C. Ian, Huang, Yu, Lee, Ji-Eun, Ge, Kai, Bruneau, Benoit G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813342/
https://www.ncbi.nlm.nih.gov/pubmed/26932671
http://dx.doi.org/10.1242/dev.132688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813342/
https://www.ncbi.nlm.nih.gov/pubmed/26932671
http://dx.doi.org/10.1242/dev.132688

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