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Uncovering the Early Assembly Mechanism for Amyloidogenic β(2)-Microglobulin Using Cross-linking and Native Mass Spectrometry
β(2)-Microglobulin (β(2)m), a key component of the major histocompatibility class I complex, can aggregate into fibrils with severe clinical consequences. As such, investigating the structural aspects of the formation of oligomeric intermediates of β(2)m and their subsequent progression toward fibri...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813486/ https://www.ncbi.nlm.nih.gov/pubmed/26655720 http://dx.doi.org/10.1074/jbc.M115.691063 |