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GPR21 KO mice demonstrate no resistance to high fat diet induced obesity or improved glucose tolerance

Gpr21 KO mice generated with Gpr21 KO ES cells obtained from Deltagen showed improved glucose tolerance and insulin sensitivity when fed a high fat diet. Further mRNA expression analysis revealed changes in Rabgap1 levels and raised the possibility that Rabgap1 gene may have been modified. To assess...

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Detalles Bibliográficos
Autores principales: Wang, Jinghong, Pan, Zheng, Baribault, Helene, Chui, Danny, Gundel, Caroline, Véniant, Murielle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813635/
https://www.ncbi.nlm.nih.gov/pubmed/27081476
http://dx.doi.org/10.12688/f1000research.7822.2