Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses

A common genetic alteration in acute myeloid leukemia is the internal tandem duplication (ITD) in FLT3, the receptor for cytokine FLT3 ligand (FLT3L). Constitutively active FLT3-ITD promotes the expansion of transformed progenitors, but also has pleiotropic effects on hematopoiesis. We analyzed the...

Descripción completa

Detalles Bibliográficos
Autores principales: Lau, Colleen M., Nish, Simone A., Yogev, Nir, Waisman, Ari, Reiner, Steven L., Reizis, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813676/
https://www.ncbi.nlm.nih.gov/pubmed/26903243
http://dx.doi.org/10.1084/jem.20150642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813676/
https://www.ncbi.nlm.nih.gov/pubmed/26903243
http://dx.doi.org/10.1084/jem.20150642

Ejemplares similares