α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current

Drug-induced long-QT syndrome (diLQTS) is often due to drug block of I(Kr), especially in genetically susceptible patients with subclinical mutations in the I(Kr)-encoding KCHN2. Few variants in the cardiac Na(V)1.5 Na(+) channel complex have been associated with diLQTS. We tested whether a novel SN...

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Detalles Bibliográficos
Autores principales: Choi, Jong-Il, Wang, Chaojian, Thomas, Matthew J., Pitt, Geoffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814026/
https://www.ncbi.nlm.nih.gov/pubmed/27028743
http://dx.doi.org/10.1371/journal.pone.0152355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814026/
https://www.ncbi.nlm.nih.gov/pubmed/27028743
http://dx.doi.org/10.1371/journal.pone.0152355

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