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α1-Syntrophin Variant Identified in Drug-Induced Long QT Syndrome Increases Late Sodium Current
Drug-induced long-QT syndrome (diLQTS) is often due to drug block of I(Kr), especially in genetically susceptible patients with subclinical mutations in the I(Kr)-encoding KCHN2. Few variants in the cardiac Na(V)1.5 Na(+) channel complex have been associated with diLQTS. We tested whether a novel SN...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814026/ https://www.ncbi.nlm.nih.gov/pubmed/27028743 http://dx.doi.org/10.1371/journal.pone.0152355 |