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Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein
Epistatic interactions between residues determine a protein’s adaptability and shape its evolutionary trajectory. When a protein experiences a changed environment, it is under strong selection to find a peak in the new fitness landscape. It has been shown that strong selection increases epistatic in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814079/ https://www.ncbi.nlm.nih.gov/pubmed/27028897 http://dx.doi.org/10.1371/journal.pgen.1005960 |