Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria

Bacteria use trans-translation and the alternative rescue factors ArfA (P36675) and ArfB (Q9A8Y3) to hydrolyze peptidyl-tRNA on ribosomes that stall near the 3' end of an mRNA during protein synthesis. The eukaryotic protein ICT1 (Q14197) is homologous to ArfB. In vitro ribosome rescue assays o...

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Detalles Bibliográficos
Autores principales: Feaga, Heather A., Quickel, Michael D., Hankey-Giblin, Pamela A., Keiler, Kenneth C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814080/
https://www.ncbi.nlm.nih.gov/pubmed/27029019
http://dx.doi.org/10.1371/journal.pgen.1005964

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814080/
https://www.ncbi.nlm.nih.gov/pubmed/27029019
http://dx.doi.org/10.1371/journal.pgen.1005964

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