LKB1 kinase-dependent and -independent defects disrupt polarity and adhesion signaling to drive collagen remodeling during invasion

LKB1 is a serine/threonine kinase and a commonly mutated gene in lung adenocarcinoma. The majority of LKB1 mutations are truncations that disrupt its kinase activity and remove its C-terminal domain (CTD). Because LKB1 inactivation drives cancer metastasis in mice and leads to aberrant cell invasion...

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Detalles Bibliográficos
Autores principales: Konen, Jessica, Wilkinson, Scott, Lee, Byoungkoo, Fu, Haian, Zhou, Wei, Jiang, Yi, Marcus, Adam I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814216/
https://www.ncbi.nlm.nih.gov/pubmed/26864623
http://dx.doi.org/10.1091/mbc.E15-08-0569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814216/
https://www.ncbi.nlm.nih.gov/pubmed/26864623
http://dx.doi.org/10.1091/mbc.E15-08-0569

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