Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells

SAHA is a class I HDAC/HDAC6 co-inhibitor and an autophagy inducer currently undergoing clinical investigations in breast cancer patients. However, the molecular mechanism of action of SAHA in breast cancer cells remains unclear. In this study, we found that SAHA is equally effective in targeting ce...

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Detalles Bibliográficos
Autores principales: Lee, Jane Ying-Chieh, Kuo, Ching-Wen, Tsai, Shing-Ling, Cheng, Siao Muk, Chen, Shang-Hung, Chan, Hsiu-Han, Lin, Chun-Hui, Lin, Kun-Yuan, Li, Chien-Feng, Kanwar, Jagat R., Leung, Euphemia Y., Cheung, Carlos Chun Ho, Huang, Wei-Jan, Wang, Yi-Ching, Cheung, Chun Hei Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814469/
https://www.ncbi.nlm.nih.gov/pubmed/27065869
http://dx.doi.org/10.3389/fphar.2016.00081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814469/
https://www.ncbi.nlm.nih.gov/pubmed/27065869
http://dx.doi.org/10.3389/fphar.2016.00081

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