Impaired 17,20-Lyase Activity in Male Mice Lacking Cytochrome b(5) in Leydig Cells

Androgen and estrogen biosynthesis in mammals requires the 17,20-lyase activity of cytochrome P450 17A1 (steroid 17-hydroxylase/17,20-lyase). Maximal 17,20-lyase activity in vitro requires the presence of cytochrome b(5) (b5), and rare cases of b5 deficiency in human beings causes isolated 17,20-lya...

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Detalles Bibliográficos
Autores principales: Sondhi, Varun, Owen, Bryn M., Liu, Jiayan, Chomic, Robert, Kliewer, Steven A., Hughes, Beverly A., Arlt, Wiebke, Mangelsdorf, David J., Auchus, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814474/
https://www.ncbi.nlm.nih.gov/pubmed/26974035
http://dx.doi.org/10.1210/me.2015-1282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814474/
https://www.ncbi.nlm.nih.gov/pubmed/26974035
http://dx.doi.org/10.1210/me.2015-1282

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