Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB)

Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofactors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is known about enzymatic damage to these molecules or...

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Detalles Bibliográficos
Autores principales: Thiaville, Jennifer J., Frelin, Océane, García-Salinas, Carolina, Harrison, Katherine, Hasnain, Ghulam, Horenstein, Nicole A., Díaz de la Garza, Rocio I., Henry, Christopher S., Hanson, Andrew D., de Crécy-Lagard, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814558/
https://www.ncbi.nlm.nih.gov/pubmed/27065985
http://dx.doi.org/10.3389/fmicb.2016.00431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814558/
https://www.ncbi.nlm.nih.gov/pubmed/27065985
http://dx.doi.org/10.3389/fmicb.2016.00431

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