RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses

Posttraumatic activation of the catabolic cascade plays a major role in degradation of cartilage. Interleukin-1β (IL-1β), a primary instigator in the catabolic axis, is upregulated in chondrocytes following injury. IL-1β activates key degradative enzymes, including MMPs and aggrecanases, and other p...

Descripción completa

Detalles Bibliográficos
Autores principales: Ortved, Kyla F., Austin, Bethany S., Scimeca, Michael S., Nixon, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814636/
https://www.ncbi.nlm.nih.gov/pubmed/27073697
http://dx.doi.org/10.1155/2016/3484961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814636/
https://www.ncbi.nlm.nih.gov/pubmed/27073697
http://dx.doi.org/10.1155/2016/3484961

Ejemplares similares