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RNA Interference Mediated Interleukin-1β Silencing in Inflamed Chondrocytes Decreases Target and Downstream Catabolic Responses

Posttraumatic activation of the catabolic cascade plays a major role in degradation of cartilage. Interleukin-1β (IL-1β), a primary instigator in the catabolic axis, is upregulated in chondrocytes following injury. IL-1β activates key degradative enzymes, including MMPs and aggrecanases, and other p...

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Detalles Bibliográficos
Autores principales:	Ortved, Kyla F., Austin, Bethany S., Scimeca, Michael S., Nixon, Alan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814636/ https://www.ncbi.nlm.nih.gov/pubmed/27073697 http://dx.doi.org/10.1155/2016/3484961

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