Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation

TDP-43 is a DNA/RNA binding protein associated with TDP-43 proteinopathies. Many mutations have been identified in the flexible C-terminal region, which is implicated in the disease pathology. We investigated four point mutations in the amyloidogenic core region (residues 311–360) of TDP-43 by bioch...

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Detalles Bibliográficos
Autores principales: Jiang, Lei-Lei, Zhao, Jian, Yin, Xiao-Fang, He, Wen-Tian, Yang, Hui, Che, Mei-Xia, Hu, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814915/
https://www.ncbi.nlm.nih.gov/pubmed/27030292
http://dx.doi.org/10.1038/srep23928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814915/
https://www.ncbi.nlm.nih.gov/pubmed/27030292
http://dx.doi.org/10.1038/srep23928

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