Imipramine alters the sterol profile in Leishmania amazonensis and increases its sensitivity to miconazole

BACKGROUND: Imipramine, a tricyclic antidepressant widely used clinically, has other pharmacological effects, such as antileishmanial activity. Tricyclic antidepressants interact with lipid bilayers, and some studies have shown that imipramine inhibits methyltransferases. Leishmania spp. produces co...

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Detalles Bibliográficos
Autores principales: Andrade-Neto, Valter Viana, Pereira, Thaís Martins, Canto-Cavalheiro, Marilene do, Torres-Santos, Eduardo Caio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815111/
https://www.ncbi.nlm.nih.gov/pubmed/27036654
http://dx.doi.org/10.1186/s13071-016-1467-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815111/
https://www.ncbi.nlm.nih.gov/pubmed/27036654
http://dx.doi.org/10.1186/s13071-016-1467-8

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