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Nucleic acids delivery methods for genome editing in zygotes and embryos: the old, the new, and the old-new
In the recent years, sequence-specific nucleases such as ZFNs, TALENs, and CRISPR/Cas9 have revolutionzed the fields of animal genome editing and transgenesis. However, these new techniques require microinjection to deliver nucleic acids into embryos to generate gene-modified animals. Microinjection...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815204/ https://www.ncbi.nlm.nih.gov/pubmed/27037013 http://dx.doi.org/10.1186/s13062-016-0115-8 |