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Proton irradiation induces persistent and tissue-specific DNA methylation changes in the left ventricle and hippocampus

BACKGROUND: Proton irradiation poses a potential hazard to astronauts during and following a mission, with post-mitotic cells at most risk because they cannot dilute resultant epigenetic changes via cell division. Persistent epigenetic changes that result from environmental exposures include gains o...

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Detalles Bibliográficos
Autores principales: Impey, Soren, Pelz, Carl, Tafessu, Amanuel, Marzulla, Tessa, Turker, Mitchell S., Raber, Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815246/
https://www.ncbi.nlm.nih.gov/pubmed/27036964
http://dx.doi.org/10.1186/s12864-016-2581-x