Leukemia inhibitory factor (LIF) withdrawal activates mTOR signaling pathway in mouse embryonic stem cells through the MEK/ERK/TSC2 pathway

Leukemia inhibitory factor (LIF) is indispensable to maintain the pluripotent state of mouse embryonic stem cells (ESCs), but the mechanisms underlying the role of LIF/STAT3 pathway are yet poorly understood. Here we first showed that the LIF/STAT3-regulated signaling pathway contributes to the main...

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Detalles Bibliográficos
Autores principales: Cherepkova, M Y, Sineva, G S, Pospelov, V A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816172/
https://www.ncbi.nlm.nih.gov/pubmed/26775702
http://dx.doi.org/10.1038/cddis.2015.387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816172/
https://www.ncbi.nlm.nih.gov/pubmed/26775702
http://dx.doi.org/10.1038/cddis.2015.387

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