Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4

Proinflammatory cytokines exert cytotoxic effects on β-cells, and are involved in the pathogenesis of type I and type II diabetes and in the drastic loss of β-cells following islet transplantation. Cytokines induce apoptosis and alter the function of differentiated β-cells. Although the MAP3 kinase...

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Detalles Bibliográficos
Autores principales: Varin, E M, Wojtusciszyn, A, Broca, C, Muller, D, Ravier, M A, Ceppo, F, Renard, E, Tanti, J-F, Dalle, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816180/
https://www.ncbi.nlm.nih.gov/pubmed/26794660
http://dx.doi.org/10.1038/cddis.2015.399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816180/
https://www.ncbi.nlm.nih.gov/pubmed/26794660
http://dx.doi.org/10.1038/cddis.2015.399

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