The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy that preferentially affects children and adolescents. Over 50% of human T-ALLs possess activating mutations of Notch1. The clerodane diterpene casearin J (CJ) is a natural product that inhibits the sarcoendoplasmatic...

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Detalles Bibliográficos
Autores principales: De Ford, C, Heidersdorf, B, Haun, F, Murillo, R, Friedrich, T, Borner, C, Merfort, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816186/
https://www.ncbi.nlm.nih.gov/pubmed/26821066
http://dx.doi.org/10.1038/cddis.2015.413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816186/
https://www.ncbi.nlm.nih.gov/pubmed/26821066
http://dx.doi.org/10.1038/cddis.2015.413

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