Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer

Nelfinavir and its analogs inhibit proliferation and induce apoptosis of castration-resistant prostate cancer through inhibition of site-2 protease (S2P) activity, which leads to suppression of regulated intramembrane proteolysis. Western blotting in nelfinavir and its analog treated cells confirms...

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Detalles Bibliográficos
Autores principales: Guan, Min, Su, Leila, Yuan, Yate-Ching, Li, Haiqing, Chow, Warren A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816264/
https://www.ncbi.nlm.nih.gov/pubmed/25880275
http://dx.doi.org/10.1038/srep09698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816264/
https://www.ncbi.nlm.nih.gov/pubmed/25880275
http://dx.doi.org/10.1038/srep09698

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