Cargando…

Nelfinavir and Nelfinavir Analogs Block Site-2 Protease Cleavage to Inhibit Castration-Resistant Prostate Cancer

Nelfinavir and its analogs inhibit proliferation and induce apoptosis of castration-resistant prostate cancer through inhibition of site-2 protease (S2P) activity, which leads to suppression of regulated intramembrane proteolysis. Western blotting in nelfinavir and its analog treated cells confirms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guan, Min, Su, Leila, Yuan, Yate-Ching, Li, Haiqing, Chow, Warren A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816264/ https://www.ncbi.nlm.nih.gov/pubmed/25880275 http://dx.doi.org/10.1038/srep09698

Ejemplares similares

The Anti-Cancer Properties of the HIV Protease Inhibitor Nelfinavir
por: Subeha, Mahbuba R., et al.
Publicado: (2020)

New Insights into the In Silico Prediction of HIV Protease Resistance to Nelfinavir
por: Antunes, Dinler A., et al.
Publicado: (2014)

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus
por: Yamamoto, Norio, et al.
Publicado: (2004)

Induction of Suicidal Erythrocyte Death by Nelfinavir
por: Bissinger, Rosi, et al.
Publicado: (2015)

Nelfinavir and other protease inhibitors in cancer: mechanisms involved in anticancer activity
por: Koltai, Tomas
Publicado: (2015)

The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma
por: Besse, Lenka, et al.
Publicado: (2023)

Nelfinavir: An Old Ally in the COVID-19 Fight?
por: Gidari, Anna, et al.
Publicado: (2022)

A phase I trial of the HIV protease inhibitor nelfinavir in adults with solid tumors
por: Blumenthal, Gideon M., et al.
Publicado: (2014)

Bilateral uveitis associated with concurrent administration of rifabutin and nelfinavir
por: Cheng, Wen-Hsin, et al.
Publicado: (2015)

Subverting ER-Stress towards Apoptosis by Nelfinavir and Curcumin Coexposure Augments Docetaxel Efficacy in Castration Resistant Prostate Cancer Cells
por: Mathur, Aditi, et al.
Publicado: (2014)

Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir
por: Grigorian, Aline, et al.
Publicado: (2008)

The HIV protease inhibitor, nelfinavir, as a novel therapeutic approach for the treatment of refractory pediatric leukemia
por: Meier-Stephenson, Vanessa, et al.
Publicado: (2017)

Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells
por: Brüning, Ansgar, et al.
Publicado: (2010)

Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus
por: Hsieh, Li-En, et al.
Publicado: (2010)

Effects of highly active antiretroviral therapy with nelfinavir in vertically HIV-1 infected children: 3 years of follow-up. Long-term response to nelfinavir in children
por: Resino, Salvador, et al.
Publicado: (2006)

Nelfinavir Impairs Glycosylation of Herpes Simplex Virus 1 Envelope Proteins and Blocks Virus Maturation
por: Gantt, Soren, et al.
Publicado: (2015)

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept(®), Roche): overview
por: Pozniak, Anton, et al.
Publicado: (2009)

Oxidative Stress Mediates the Antiproliferative Effects of Nelfinavir in Breast Cancer Cells
por: Soprano, Maria, et al.
Publicado: (2016)

Nelfinavir restricts A549 cell growth by inhibiting STAT3 signaling
por: He, Fangli, et al.
Publicado: (2021)

Nelfinavir Inhibition of Kaposi’s sarcoma-associated herpesvirus protein expression and capsid assembly
por: Li, Maggie, et al.
Publicado: (2023)

Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease
por: Gupta, Ankita, et al.
Publicado: (2015)

Nelfinavir, an HIV-1 Protease Inhibitor, Induces Oxidative Stress–Mediated, Caspase-Independent Apoptosis in Leishmania Amastigotes
por: Kumar, Pranav, et al.
Publicado: (2010)

Effect of nelfinavir stereoisomers on coronavirus main protease: Molecular docking, molecular dynamics simulation and MM/GBSA study
por: Sargolzaei, Mohsen
Publicado: (2021)

Potential anti-COVID-19 agents, cepharanthine and nelfinavir, and their usage for combination treatment
por: Ohashi, Hirofumi, et al.
Publicado: (2021)

Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells
por: Kawabata, S, et al.
Publicado: (2012)

Overcoming Proteasome Inhibitor-Refractory Multiple Myeloma With Elotuzumab, Bortezomib, Nelfinavir, and Dexamethasone
por: Erath, Alexandra, et al.
Publicado: (2020)

Nelfinavir augments proteasome inhibition by bortezomib in myeloma cells and overcomes bortezomib and carfilzomib resistance
por: Kraus, M, et al.
Publicado: (2013)

Targeting the coronavirus SARS-CoV-2: computational insights into the mechanism of action of the protease inhibitors lopinavir, ritonavir and nelfinavir
por: Bolcato, Giovanni, et al.
Publicado: (2020)

HIV protease inhibitor nelfinavir is a potent drug candidate against echinococcosis by targeting Ddi1-like protein
por: Liu, Zhongli, et al.
Publicado: (2022)

ARCII: A phase II trial of the HIV protease inhibitor Nelfinavir in combination with chemoradiation for locally advanced inoperable pancreatic cancer
por: Wilson, James M., et al.
Publicado: (2016)

Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma
por: Besse, Lenka, et al.
Publicado: (2021)

Nelfinavir Inhibits the TCF11/Nrf1-Mediated Proteasome Recovery Pathway in Multiple Myeloma
por: Fassmannová, Dominika, et al.
Publicado: (2020)

Maternal Lopinavir/Ritonavir Is Associated with Fewer Adverse Events in Infants than Nelfinavir or Atazanavir
por: Smith, Christiana, et al.
Publicado: (2016)

Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress
por: Sato, Akinori, et al.
Publicado: (2018)

The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo
por: Liebscher, Steffi, et al.
Publicado: (2017)

Inhibition of the NOTCH and mTOR pathways by nelfinavir as a novel treatment for T cell acute lymphoblastic leukemia
por: Chang, Yoon Soo, et al.
Publicado: (2023)

Estimating the individualized HIV-1 genetic barrier to resistance using a nelfinavir fitness landscape
por: Theys, Kristof, et al.
Publicado: (2010)

Fabrication and in vivo evaluation of Nelfinavir loaded PLGA nanoparticles for enhancing oral bioavailability and therapeutic effect
por: Venkatesh, D. Nagasamy, et al.
Publicado: (2015)

Nelfinavir Inhibits Intra-Mitochondrial Calcium Influx and Protects Brain against Hypoxic-Ischemic Injury in Neonatal Mice
por: Utkina-Sosunova, Irina V., et al.
Publicado: (2013)

The FDA-Approved Drug Nelfinavir Inhibits Lytic Cell-Free but Not Cell-Associated Nonlytic Transmission of Human Adenovirus
por: Georgi, Fanny, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_03fr2hv5kmeqh77l8rp7b62mim