Presequence-Independent Mitochondrial Import of DNA Ligase Facilitates Establishment of Cell Lines with Reduced mtDNA Copy Number

Due to the essential role played by mitochondrial DNA (mtDNA) in cellular physiology and bioenergetics, methods for establishing cell lines with altered mtDNA content are of considerable interest. Here, we report evidence for the existence in mammalian cells of a novel, low- efficiency, presequence-...

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Detalles Bibliográficos
Autores principales: Spadafora, Domenico, Kozhukhar, Natalia, Alexeyev, Mikhail F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816344/
https://www.ncbi.nlm.nih.gov/pubmed/27031233
http://dx.doi.org/10.1371/journal.pone.0152705

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816344/
https://www.ncbi.nlm.nih.gov/pubmed/27031233
http://dx.doi.org/10.1371/journal.pone.0152705

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