miR-378 Activates the Pyruvate-PEP Futile Cycle and Enhances Lipolysis to Ameliorate Obesity in Mice

Obesity has been linked to many health problems, such as diabetes. However, there is no drug that effectively treats obesity. Here, we reveal that miR-378 transgenic mice display reduced fat mass, enhanced lipolysis, and increased energy expenditure. Notably, administering AgomiR-378 prevents and am...

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Detalles Bibliográficos
Autores principales: Zhang, Yong, Li, Changyin, Li, Hu, Song, Yipeng, Zhao, Yixia, Zhai, Lili, Wang, Haixia, Zhong, Ran, Tang, Huiru, Zhu, Dahai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816830/
https://www.ncbi.nlm.nih.gov/pubmed/27077116
http://dx.doi.org/10.1016/j.ebiom.2016.01.035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816830/
https://www.ncbi.nlm.nih.gov/pubmed/27077116
http://dx.doi.org/10.1016/j.ebiom.2016.01.035

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