Inhibition of mTOR activity in diabetes mellitus reduces proteinuria but not renal accumulation of hyaluronan

Objectives. Accumulation of extracellular matrix (ECM) components is an early sign of diabetic nephropathy. Also the glycosaminoglycan hyaluronan (HA) is elevated in the renal interstitium during experimental diabetes. The mammalian target of rapamycin (mTOR) pathway participates in the signaling of...

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Detalles Bibliográficos
Autores principales: Stridh, Sara, Palm, Fredrik, Takahashi, Tomoko, Ikegami-Kawai, Mayumi, Hansell, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816883/
https://www.ncbi.nlm.nih.gov/pubmed/26175092
http://dx.doi.org/10.3109/03009734.2015.1062442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816883/
https://www.ncbi.nlm.nih.gov/pubmed/26175092
http://dx.doi.org/10.3109/03009734.2015.1062442

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