Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands

Controlling biochemical pathways through chemically designed modulators may provide novel opportunities to develop therapeutic drugs and chemical tools. The underlying challenge is to design new molecular entities able to act as allosteric chemical switches that selectively turn on/off functions by...

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Detalles Bibliográficos
Autores principales: Vettoretti, Gerolamo, Moroni, Elisabetta, Sattin, Sara, Tao, Jiahui, Agard, David A., Bernardi, Anna, Colombo, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817115/
https://www.ncbi.nlm.nih.gov/pubmed/27032695
http://dx.doi.org/10.1038/srep23830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817115/
https://www.ncbi.nlm.nih.gov/pubmed/27032695
http://dx.doi.org/10.1038/srep23830

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