Human DNA polymerase α in binary complex with a DNA:DNA template-primer

The Polα/primase complex assembles the short RNA-DNA fragments for priming of lagging and leading strand DNA replication in eukaryotes. As such, the Polα polymerase subunit encounters two types of substrates during primer synthesis: an RNA:DNA helix and a DNA:DNA helix. The engagement of the polymer...

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Detalles Bibliográficos
Autores principales: Coloma, Javier, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817131/
https://www.ncbi.nlm.nih.gov/pubmed/27032819
http://dx.doi.org/10.1038/srep23784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817131/
https://www.ncbi.nlm.nih.gov/pubmed/27032819
http://dx.doi.org/10.1038/srep23784

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