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Human DNA polymerase α in binary complex with a DNA:DNA template-primer

The Polα/primase complex assembles the short RNA-DNA fragments for priming of lagging and leading strand DNA replication in eukaryotes. As such, the Polα polymerase subunit encounters two types of substrates during primer synthesis: an RNA:DNA helix and a DNA:DNA helix. The engagement of the polymer...

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Detalles Bibliográficos
Autores principales:	Coloma, Javier, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Aggarwal, Aneel K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817131/ https://www.ncbi.nlm.nih.gov/pubmed/27032819 http://dx.doi.org/10.1038/srep23784

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