Cargando…

Structural Studies of Lipopolysaccharide-defective Mutants from Brucella melitensis Identify a Core Oligosaccharide Critical in Virulence

The structures of the lipooligosaccharides from Brucella melitensis mutants affected in the WbkD and ManB(core) proteins have been fully characterized using NMR spectroscopy. The results revealed that disruption of wbkD gives rise to a rough lipopolysaccharide (R-LPS) with a complete core structure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fontana, Carolina, Conde-Álvarez, Raquel, Ståhle, Jonas, Holst, Otto, Iriarte, Maite, Zhao, Yun, Arce-Gorvel, Vilma, Hanniffy, Seán, Gorvel, Jean-Pierre, Moriyón, Ignacio, Widmalm, Göran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817197/ https://www.ncbi.nlm.nih.gov/pubmed/26867577 http://dx.doi.org/10.1074/jbc.M115.701540

Ejemplares similares

Immunomodulatory properties of Brucella melitensis lipopolysaccharide determinants on mouse dendritic cells in vitro and in vivo
por: Zhao, Yun, et al.
Publicado: (2017)

2-Acylamido Analogues of N-Acetylglucosamine Prime Formation of Chitin Oligosaccharides by Yeast Chitin Synthase 2
por: Gyore, Jacob, et al.
Publicado: (2014)

A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan: USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION
por: Higman, Victoria A., et al.
Publicado: (2014)

Identification of Mono- and Disulfated N-Acetyl-lactosaminyl Oligosaccharide Structures as Epitopes Specifically Recognized by Humanized Monoclonal Antibody HMOCC-1 Raised against Ovarian Cancer
por: Shibata, Toshiaki K., et al.
Publicado: (2012)

Binding of N-Acetylglucosamine (GlcNAc) β1–6-branched Oligosaccharide Acceptors to β4-Galactosyltransferase I Reveals a New Ligand Binding Mode
por: Ramakrishnan, Boopathy, et al.
Publicado: (2012)

Dectin-2 Recognizes Mannosylated O-antigens of Human Opportunistic Pathogens and Augments Lipopolysaccharide Activation of Myeloid Cells
por: Wittmann, Alexandra, et al.
Publicado: (2016)

Structural determinants in a glucose-containing lipopolysaccharide from Mycobacterium tuberculosis critical for inducing a subset of protective T cells
por: De, Prithwiraj, et al.
Publicado: (2018)

Brucellosis Vaccines: Assessment of Brucella melitensis Lipopolysaccharide Rough Mutants Defective in Core and O-Polysaccharide Synthesis and Export
por: González, David, et al.
Publicado: (2008)

Genomic Insertion of a Heterologous Acetyltransferase Generates a New Lipopolysaccharide Antigenic Structure in Brucella abortus and Brucella melitensis
por: Martínez-Gómez, Estrella, et al.
Publicado: (2018)

CLEC9A Is a Novel Activation C-type Lectin-like Receptor Expressed on BDCA3(+) Dendritic Cells and a Subset of Monocytes
por: Huysamen, Cristal, et al.
Publicado: (2008)

The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in Parasite Protein Glycosylation
por: Stokes, Matthew J., et al.
Publicado: (2008)

TSG-6 Regulates Bone Remodeling through Inhibition of Osteoblastogenesis and Osteoclast Activation
por: Mahoney, David J., et al.
Publicado: (2008)

A Mucin-type O-Glycosyltransferase Modulates Cell Adhesion during Drosophila Development
por: Zhang, Liping, et al.
Publicado: (2008)

Identification of Neutrophil Granule Glycoproteins as Lewis(x)-containing Ligands Cleared by the Scavenger Receptor C-type Lectin
por: Graham, Sarah A., et al.
Publicado: (2011)

Peracetylated 4-Fluoro-glucosamine Reduces the Content and Repertoire of N- and O-Glycans without Direct Incorporation
por: Barthel, Steven R., et al.
Publicado: (2011)

Early Murine T-lymphocyte Activation Is Accompanied by a Switch from N-Glycolyl- to N-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E
por: Redelinghuys, Pierre, et al.
Publicado: (2011)

Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
por: Pedersen, Johannes W., et al.
Publicado: (2011)

Post-assembly Modification of Bordetella bronchiseptica O Polysaccharide by a Novel Periplasmic Enzyme Encoded by wbmE
por: King, Jerry D., et al.
Publicado: (2009)

Interleukin-6 Released from Fibroblasts Is Essential for Up-regulation of Matrix Metalloproteinase-1 Expression by U937 Macrophages in Coculture: CROSS-TALKING BETWEEN FIBROBLASTS AND U937 MACROPHAGES EXPOSED TO HIGH GLUCOSE
por: Sundararaj, Kamala P., et al.
Publicado: (2009)

Loss of α-Dystroglycan Laminin Binding in Epithelium-derived Cancers Is Caused by Silencing of LARGE
por: de Bernabé, Daniel Beltrán-Valero, et al.
Publicado: (2009)

A Human Embryonic Kidney 293T Cell Line Mutated at the Golgi α-Mannosidase II Locus
por: Crispin, Max, et al.
Publicado: (2009)

Rapid Purification and High Sensitivity Analysis of Heparan Sulfate from Cells and Tissues: TOWARD GLYCOMICS PROFILING
por: Guimond, Scott E., et al.
Publicado: (2009)

Trimeric Structure of Langerin
por: Feinberg, Hadar, et al.
Publicado: (2010)

Heparan Sulfate Chain Valency Controls Syndecan-4 Function in Cell Adhesion
por: Gopal, Sandeep, et al.
Publicado: (2010)

α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling
por: Kitazume, Shinobu, et al.
Publicado: (2010)

Glycomics Profiling of Chinese Hamster Ovary Cell Glycosylation Mutants Reveals N-Glycans of a Novel Size and Complexity
por: North, Simon J., et al.
Publicado: (2010)

Revised Role of Glycosaminoglycans in TAT Protein Transduction Domain-mediated Cellular Transduction
por: Gump, Jacob M., et al.
Publicado: (2010)

Prolectin, a Glycan-binding Receptor on Dividing B Cells in Germinal Centers
por: Graham, Sarah A., et al.
Publicado: (2009)

In Planta Protein Sialylation through Overexpression of the Respective Mammalian Pathway
por: Castilho, Alexandra, et al.
Publicado: (2010)

Role of the Netrin-like Domain of Procollagen C-Proteinase Enhancer-1 in the Control of Metalloproteinase Activity
por: Bekhouche, Mourad, et al.
Publicado: (2010)

Constitutive Expression of Inter-α-inhibitor (IαI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex
por: Zhang, Suzhen, et al.
Publicado: (2012)

Monocyte-to-Macrophage Differentiation: SYNTHESIS AND SECRETION OF A COMPLEX EXTRACELLULAR MATRIX
por: Chang, Mary Y., et al.
Publicado: (2012)

Transglutaminase-2 Interaction with Heparin: IDENTIFICATION OF A HEPARIN BINDING SITE THAT REGULATES CELL ADHESION TO FIBRONECTIN-TRANSGLUTAMINASE-2 MATRIX
por: Lortat-Jacob, Hugues, et al.
Publicado: (2012)

Chemical Structure of Trichomonas vaginalis Surface Lipoglycan: A ROLE FOR SHORT GALACTOSE (β1–4/3) N-ACETYLGLUCOSAMINE REPEATS IN HOST CELL INTERACTION
por: Ryan, Christopher M., et al.
Publicado: (2011)

Collagen VI, Conformation of A-domain Arrays and Microfibril Architecture
por: Beecher, Nicola, et al.
Publicado: (2011)

The Streptococcal Binding Site in the Gelatin-binding Domain of Fibronectin Is Consistent with a Non-linear Arrangement of Modules
por: Atkin, Kate E., et al.
Publicado: (2010)

β-N-Acetylhexosaminidases HEXO1 and HEXO3 Are Responsible for the Formation of Paucimannosidic N-Glycans in Arabidopsis thaliana
por: Liebminger, Eva, et al.
Publicado: (2011)

Redefinition of the Carbohydrate Binding Specificity of Helicobacter pylori BabA Adhesin
por: Benktander, John, et al.
Publicado: (2012)

Constitutive Dimerization of Glycoprotein VI (GPVI) in Resting Platelets Is Essential for Binding to Collagen and Activation in Flowing Blood
por: Jung, Stephanie M., et al.
Publicado: (2012)

Significant Impact of Single N-Glycan Residues on the Biological Activity of Fc-based Antibody-like Fragments
por: Jez, Jakub, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_cc2aqjt2evg86p7e9ecso5la2n