Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide

Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain. We determined the structure of aquaporin-4 in the presence of AZA using electron crystallography. Most of the features of the 5-Å density map were consistent with those of the previously de...

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Detalles Bibliográficos
Autores principales: Kamegawa, Akiko, Hiroaki, Yoko, Tani, Kazutoshi, Fujiyoshi, Yoshinori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817316/
https://www.ncbi.nlm.nih.gov/pubmed/26908838
http://dx.doi.org/10.1093/jmicro/dfv368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817316/
https://www.ncbi.nlm.nih.gov/pubmed/26908838
http://dx.doi.org/10.1093/jmicro/dfv368

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