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Two-dimensional crystal structure of aquaporin-4 bound to the inhibitor acetazolamide
Acetazolamide (AZA) reduces the water permeability of aquaporin-4, the predominant water channel in the brain. We determined the structure of aquaporin-4 in the presence of AZA using electron crystallography. Most of the features of the 5-Å density map were consistent with those of the previously de...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817316/ https://www.ncbi.nlm.nih.gov/pubmed/26908838 http://dx.doi.org/10.1093/jmicro/dfv368 |