Cargando…

Reciprocal regulation of RORγt acetylation and function by p300 and HDAC1

T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved in the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor involved in Th17 cell differentiation through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Qingsi, Nie, Jia, Gao, Yayi, Xu, Peng, Sun, Qijuan, Yang, Jing, Han, Lei, Chen, Zuojia, Wang, Xiuwen, Lv, Ling, Tsun, Andy, Shen, Jijia, Li, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817527/ https://www.ncbi.nlm.nih.gov/pubmed/26549310 http://dx.doi.org/10.1038/srep16355

Ejemplares similares

Digoxin, an Overlooked Agonist of RORγ/RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

SUMOylation of ROR-γt inhibits IL-17 expression and inflammation via HDAC2
por: Singh, Amir Kumar, et al.
Publicado: (2018)

The Dichotomous Nature of AZ5104 (an EGFR Inhibitor) Towards RORγ and RORγT
por: Karaś, Kaja, et al.
Publicado: (2019)

Pparα knockout in mice increases the Th17 development by facilitating the IKKα/RORγt and IKKα/Foxp3 complexes
por: Wei, Ping, et al.
Publicado: (2023)

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis
por: Ruan, Qingguo, et al.
Publicado: (2011)

The application of machine learning methods to the prediction of novel ligands for RORγ/RORγT receptors
por: Bachorz, Rafał A., et al.
Publicado: (2023)

RORα and RORγ expression inversely correlates with human melanoma progression
por: Brożyna, Anna A., et al.
Publicado: (2016)

RORγt and RORα signature genes in human Th17 cells
por: Castro, Glenda, et al.
Publicado: (2017)

The immunomodulatory effects of TNF-α inhibitors on human Th17 cells via RORγt histone acetylation
por: Lin, Yi-Ching, et al.
Publicado: (2016)

RORγ Structural Plasticity and Druggability
por: Huang, Mian, et al.
Publicado: (2020)

Interplay between p300 and HDAC1 regulate acetylation and stability of Api5 to regulate cell proliferation
por: Sharma, Virender Kumar, et al.
Publicado: (2021)

Silencing RORγt in Human CD4(+) T cells with CD30 aptamer-RORγt shRNA Chimera
por: Shi, Xiaofei, et al.
Publicado: (2019)

P300/HDAC1 regulates the acetylation/deacetylation and autophagic activities of LC3/Atg8–PE ubiquitin-like system
por: Wu, Wenmei, et al.
Publicado: (2021)

Protein Acetylation and the Physiological Role of HDACs
por: Matthias, Patrick, et al.
Publicado: (2011)

Identification of an allosteric binding site for RORγt inhibition
por: Scheepstra, Marcel, et al.
Publicado: (2015)

Sodium butyrate alleviates deoxynivalenol-induced hepatic cholesterol metabolic dysfunction via RORγ-mediated histone acetylation modification in weaning piglets
por: Zong, Qiufang, et al.
Publicado: (2022)

HAT- and HDAC-Targeted Protein Acetylation in the Occurrence and Treatment of Epilepsy
por: Wang, Jie, et al.
Publicado: (2022)

The therapeutic potential of RORγ modulators in the treatment of human disease
por: Chang, Mi Ra, et al.
Publicado: (2012)

Effects of RORγt overexpression on the murine central nervous system
por: Sasaki, Tetsuya, et al.
Publicado: (2021)

RORγt phosphorylation protects against T cell-mediated inflammation
por: Ma, Shengyun, et al.
Publicado: (2022)

Identification of RORγ as a favorable biomarker for colon cancer
por: Pan, Xiaofei, et al.
Publicado: (2021)

Preclinical and clinical characterization of the RORγt inhibitor JNJ-61803534
por: Xue, Xiaohua, et al.
Publicado: (2021)

An inhibitor of RORγ for chronic pulmonary obstructive disease treatment
por: Desai, Harshada, et al.
Publicado: (2022)

Statistical Analysis of Protein-Ligand Interaction Patterns in Nuclear Receptor RORγ
por: Pham, Bill, et al.
Publicado: (2022)

CBP/p300 and HDAC activities regulate H3K27 acetylation dynamics and zygotic genome activation in mouse preimplantation embryos
por: Wang, Meng, et al.
Publicado: (2022)

Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2015)

Reciprocal Regulation of AMPK/SNF1 and Protein Acetylation
por: Vancura, Ales, et al.
Publicado: (2018)

Attenuation of Rheumatoid Inflammation by Sodium Butyrate Through Reciprocal Targeting of HDAC2 in Osteoclasts and HDAC8 in T Cells
por: Kim, Da Som, et al.
Publicado: (2018)

Host histone acetylation unlocks HDAC inhibitor potential
por: Terranova-Barberio, Manuela, et al.
Publicado: (2017)

Expression of Th-17 and RORγt mRNA in Behçet’s Disease
por: Hamzaoui, Kamel, et al.
Publicado: (2011)

Involvement of RORγt-overexpressing T cells in the development of autoimmune arthritis in mice
por: Kondo, Yuya, et al.
Publicado: (2015)

Sumoylation of RORγt regulates T(H)17 differentiation and thymocyte development
por: He, Zhiheng, et al.
Publicado: (2018)

Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt
por: de Vries, Rens M. J. M., et al.
Publicado: (2021)

Intestinal factors promoting the development of RORγt(+) cells and oral tolerance
por: López-Fandiño, Rosina, et al.
Publicado: (2023)

Correction to Protein Lysine Acetylation by p300/CBP
por: Dancy, Beverley M., et al.
Publicado: (2016)

Ontogeny of RORγt(+) cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis
por: Zhao, Xiuhao, et al.
Publicado: (2022)

Small molecule inhibitors of RORγt for Th17 regulation in inflammatory and autoimmune diseases
por: Zeng, Jiuping, et al.
Publicado: (2023)

Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitis
por: Yang, Wen-Lan, et al.
Publicado: (2023)

The hepatic circadian clock fine-tunes the lipogenic response to feeding through RORα/γ
por: Zhang, Yuxiang, et al.
Publicado: (2017)

Transcription of RORγt in Developing Th17 Cells is Regulated by E-Proteins
por: Zhang, Fuping, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1h0u1f0tb5rhcj6ekgovqomskj