Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

Being a transient carrier of genetic information, mRNA could be a versatile, flexible, and safe means for protein therapies. While recent findings highlight the enormous therapeutic potential of mRNA, evidence that mRNA-based protein therapies are feasible beyond small animals such as mice is still...

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Detalles Bibliográficos
Autores principales: Thess, Andreas, Grund, Stefanie, Mui, Barbara L, Hope, Michael J, Baumhof, Patrick, Fotin-Mleczek, Mariola, Schlake, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817881/
https://www.ncbi.nlm.nih.gov/pubmed/26050989
http://dx.doi.org/10.1038/mt.2015.103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817881/
https://www.ncbi.nlm.nih.gov/pubmed/26050989
http://dx.doi.org/10.1038/mt.2015.103

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