A HER2-specific Modified Fc Fragment (Fcab) Induces Antitumor Effects Through Degradation of HER2 and Apoptosis

FS102 is a HER2-specific Fcab (Fc fragment with antigen binding), which binds HER2 with high affinity and recognizes an epitope that does not overlap with those of trastuzumab or pertuzumab. In tumor cells that express high levels of HER2, FS102 caused profound HER2 internalization and degradation l...

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Detalles Bibliográficos
Autores principales: Leung, Kin-Mei, Batey, Sarah, Rowlands, Robert, Isaac, Samine J, Jones, Phil, Drewett, Victoria, Carvalho, Joana, Gaspar, Miguel, Weller, Sarah, Medcalf, Melanie, Wydro, Mateusz M, Pegram, Robert, Mudde, Geert C, Bauer, Anton, Moulder, Kevin, Woisetschläger, Max, Tuna, Mihriban, Haurum, John S, Sun, Haijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817942/
https://www.ncbi.nlm.nih.gov/pubmed/26234505
http://dx.doi.org/10.1038/mt.2015.127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817942/
https://www.ncbi.nlm.nih.gov/pubmed/26234505
http://dx.doi.org/10.1038/mt.2015.127

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