AAV2/1 CD74 Gene Transfer Reduces β-amyloidosis and Improves Learning and Memory in a Mouse Model of Alzheimer's Disease

Modulation of the amyloid-β (Aβ) trafficking pathway heralds a new therapeutic frontier for Alzheimer's disease (AD). As CD74 binds to the amyloid-β precursor protein (APP) and can suppresses Aβ processing, we investigated whether recombinant adeno-associated virus (AAV) delivery of CD74 could...

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Detalles Bibliográficos
Autores principales: Kiyota, Tomomi, Zhang, Gang, Morrison, Christine M, Bosch, Megan E, Weir, Robert A, Lu, Yaman, Dong, Weiguo, Gendelman, Howard E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817947/
https://www.ncbi.nlm.nih.gov/pubmed/26227349
http://dx.doi.org/10.1038/mt.2015.142

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817947/
https://www.ncbi.nlm.nih.gov/pubmed/26227349
http://dx.doi.org/10.1038/mt.2015.142

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