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Excessive Osteocytic Fgf23 Secretion Contributes to Pyrophosphate Accumulation and Mineralization Defect in Hyp Mice

X-linked hypophosphatemia (XLH) is the most frequent form of inherited rickets in humans caused by mutations in the phosphate-regulating gene with homologies to endopeptidases on the X-chromosome (PHEX). Hyp mice, a murine homologue of XLH, are characterized by hypophosphatemia, inappropriately low...

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Detalles Bibliográficos
Autores principales: Murali, Sathish K., Andrukhova, Olena, Clinkenbeard, Erica L., White, Kenneth E., Erben, Reinhold G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818020/
https://www.ncbi.nlm.nih.gov/pubmed/27035636
http://dx.doi.org/10.1371/journal.pbio.1002427