Leprosy Reactions Show Increased Th17 Cell Activity and Reduced FOXP3+ Tregs with Concomitant Decrease in TGF-β and Increase in IL-6

BACKGROUND: 50% of leprosy patients suffer from episodes of Type 1/ reversal reactions (RR) and Type 2/ Erythema Nodosum Leprosum (ENL) reactions which lead to morbidity and nerve damage. CD4(+) subsets of Th17 cells and CD25(+)FOXP3(+) regulatory T cells (Tregs) have been shown to play a major role...

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Detalles Bibliográficos
Autores principales: Saini, Chaman, Siddiqui, Anisuddin, Ramesh, Venkatesh, Nath, Indira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818038/
https://www.ncbi.nlm.nih.gov/pubmed/27035913
http://dx.doi.org/10.1371/journal.pntd.0004592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818038/
https://www.ncbi.nlm.nih.gov/pubmed/27035913
http://dx.doi.org/10.1371/journal.pntd.0004592

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