Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response

Common alkylating antitumor drugs, such as temozolomide, trigger their cytotoxicity by methylating the O6-position of guanosine in DNA. However, the therapeutic effect of these drugs is dampened by elevated levels of the DNA repair enzyme, O(6)-methylguanine DNA methyltransferase (MGMT), which direc...

Descripción completa

Detalles Bibliográficos
Autores principales: Beharry, Andrew A., Nagel, Zachary D., Samson, Leona D., Kool, Eric T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818092/
https://www.ncbi.nlm.nih.gov/pubmed/27035132
http://dx.doi.org/10.1371/journal.pone.0152684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818092/
https://www.ncbi.nlm.nih.gov/pubmed/27035132
http://dx.doi.org/10.1371/journal.pone.0152684

Ejemplares similares