HER2+ Cancer Cell Dependence on PI3K vs. MAPK Signaling Axes Is Determined by Expression of EGFR, ERBB3 and CDKN1B

Understanding the molecular pathways by which oncogenes drive cancerous cell growth, and how dependence on such pathways varies between tumors could be highly valuable for the design of anti-cancer treatment strategies. In this work we study how dependence upon the canonical PI3K and MAPK cascades v...

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Detalles Bibliográficos
Autores principales: Kirouac, Daniel C., Du, Jinyan, Lahdenranta, Johanna, Onsum, Matthew D., Nielsen, Ulrik B., Schoeberl, Birgit, McDonagh, Charlotte F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818107/
https://www.ncbi.nlm.nih.gov/pubmed/27035903
http://dx.doi.org/10.1371/journal.pcbi.1004827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818107/
https://www.ncbi.nlm.nih.gov/pubmed/27035903
http://dx.doi.org/10.1371/journal.pcbi.1004827

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