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Hmga2 is necessary for Otx2-dependent exit of embryonic stem cells from the pluripotent ground state
BACKGROUND: A crucial event in the differentiation of mouse embryonic stem cells (ESCs) is the exit from the pluripotent ground state that leads to the acquisition of the ‘primed’ pluripotent phenotype, characteristic of the epiblast-like stem cells (EpiLCs). The transcription factors Oct4 and Otx2...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818510/ https://www.ncbi.nlm.nih.gov/pubmed/27036552 http://dx.doi.org/10.1186/s12915-016-0246-5 |