Kainate receptor pore‐forming and auxiliary subunits regulate channel block by a novel mechanism

KEY POINTS: Kainate receptor heteromerization and auxiliary subunits, Neto1 and Neto2, attenuate polyamine ion‐channel block by facilitating blocker permeation. Relief of polyamine block in GluK2/GluK5 heteromers results from a key proline residue that produces architectural changes in the channel p...

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Detalles Bibliográficos
Autores principales: Brown, Patricia M. G. E., Aurousseau, Mark R. P., Musgaard, Maria, Biggin, Philip C., Bowie, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Neuroscience ‐ Cellular/Molecular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818602/
https://www.ncbi.nlm.nih.gov/pubmed/26682513
http://dx.doi.org/10.1113/JP271690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818602/
https://www.ncbi.nlm.nih.gov/pubmed/26682513
http://dx.doi.org/10.1113/JP271690

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