Antioxidants inhibit neuronal toxicity in Parkinson's disease‐linked LRRK2

Mutations in leucine‐rich repeat kinase‐2 are the most common cause of familial Parkinson's disease. The prevalent G2019S mutation increase oxidative, kinase and toxic activity and inhibit endogenous peroxidases. We initially screened a library of 84 antioxidants and identified seven phenolic c...

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Detalles Bibliográficos
Autores principales: Angeles, Dario C., Ho, Patrick, Dymock, Brian W., Lim, Kah‐Leong, Zhou, Zhi‐Dong, Tan, Eng‐King
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818746/
https://www.ncbi.nlm.nih.gov/pubmed/27081659
http://dx.doi.org/10.1002/acn3.282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818746/
https://www.ncbi.nlm.nih.gov/pubmed/27081659
http://dx.doi.org/10.1002/acn3.282

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