Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice

A152T‐variant human tau (hTau‐A152T) increases risk for tauopathies, including Alzheimer's disease. Comparing mice with regulatable expression of hTau‐A152T or wild‐type hTau (hTau‐WT), we find age‐dependent neuronal loss, cognitive impairments, and spontaneous nonconvulsive epileptiform activi...

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Detalles Bibliográficos
Autores principales: Maeda, Sumihiro, Djukic, Biljana, Taneja, Praveen, Yu, Gui‐Qiu, Lo, Iris, Davis, Allyson, Craft, Ryan, Guo, Weikun, Wang, Xin, Kim, Daniel, Ponnusamy, Ravikumar, Gill, T Michael, Masliah, Eliezer, Mucke, Lennart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818780/
https://www.ncbi.nlm.nih.gov/pubmed/26931567
http://dx.doi.org/10.15252/embr.201541438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818780/
https://www.ncbi.nlm.nih.gov/pubmed/26931567
http://dx.doi.org/10.15252/embr.201541438

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