The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions

Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid mali...

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Autores principales: Lu, Kai, Basu, Sujit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819393/
https://www.ncbi.nlm.nih.gov/pubmed/25859636
http://dx.doi.org/10.1038/srep09642
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author Lu, Kai
Basu, Sujit
author_facet Lu, Kai
Basu, Sujit
author_sort Lu, Kai
collection PubMed
description Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis.
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spelling pubmed-48193932016-04-06 The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions Lu, Kai Basu, Sujit Sci Rep Article Vascular endothelial growth factor A (VEGFA) plays an important role in tumour angiogenesis and its angiogenic action is mainly mediated through its VEGF receptor 2 (VEGFR-2). Therefore drugs targeting VEGFA/VEGFR-2 are being presently used in the clinics for treatment of several types of solid malignant tumours. We here in report that low dose of chebulagic acid (CA), a hydrolysable tannin found in myrobalan fruits can inhibit VEGFA induced vascular permeability, endothelial cell proliferation, migration, tube formation and thereby, angiogenesis by suppressing VEGFR-2 phosphorylation. CA may thus be an effective and useful natural inhibitor of VEGFA mediated angiogenesis. Nature Publishing Group 2015-04-10 /pmc/articles/PMC4819393/ /pubmed/25859636 http://dx.doi.org/10.1038/srep09642 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lu, Kai
Basu, Sujit
The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
title The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
title_full The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
title_fullStr The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
title_full_unstemmed The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
title_short The natural compound chebulagic acid inhibits vascular endothelial growth factor A mediated regulation of endothelial cell functions
title_sort natural compound chebulagic acid inhibits vascular endothelial growth factor a mediated regulation of endothelial cell functions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819393/
https://www.ncbi.nlm.nih.gov/pubmed/25859636
http://dx.doi.org/10.1038/srep09642
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