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Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes

Neurotransmitter-gated ion channels adopt different gating modes to fine-tune signaling at central synapses. At glutamatergic synapses, high and low activity of AMPA receptors (AMPARs) is observed when pore-forming subunits coassemble with or without auxiliary subunits, respectively. Whether a commo...

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Detalles Bibliográficos
Autores principales: Dawe, G. Brent, Musgaard, Maria, Aurousseau, Mark R.P., Nayeem, Naushaba, Green, Tim, Biggin, Philip C., Bowie, Derek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819453/
https://www.ncbi.nlm.nih.gov/pubmed/26924438
http://dx.doi.org/10.1016/j.neuron.2016.01.038