Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested...

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Detalles Bibliográficos
Autores principales: Berg, Russell D., Levitte, Steven, O’Sullivan, Mary P., O’Leary, Seónadh M., Cambier, C.J., Cameron, James, Takaki, Kevin K., Moens, Cecilia B., Tobin, David M., Keane, Joseph, Ramakrishnan, Lalita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819607/
https://www.ncbi.nlm.nih.gov/pubmed/27015311
http://dx.doi.org/10.1016/j.cell.2016.02.034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819607/
https://www.ncbi.nlm.nih.gov/pubmed/27015311
http://dx.doi.org/10.1016/j.cell.2016.02.034

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