Cargando…

Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration

A zebrafish genetic screen for determinants of susceptibility to Mycobacterium marinum identified a hypersusceptible mutant deficient in lysosomal cysteine cathepsins that manifests hallmarks of human lysosomal storage diseases. Under homeostatic conditions, mutant macrophages accumulate undigested...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berg, Russell D., Levitte, Steven, O’Sullivan, Mary P., O’Leary, Seónadh M., Cambier, C.J., Cameron, James, Takaki, Kevin K., Moens, Cecilia B., Tobin, David M., Keane, Joseph, Ramakrishnan, Lalita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819607/ https://www.ncbi.nlm.nih.gov/pubmed/27015311 http://dx.doi.org/10.1016/j.cell.2016.02.034

Ejemplares similares

Phenolic Glycolipid Facilitates Mycobacterial Escape from Microbicidal Tissue-Resident Macrophages
por: Cambier, C.J., et al.
Publicado: (2017)

Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing
por: Lawlor, Ciaran, et al.
Publicado: (2016)

Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo
por: Levitte, Steven, et al.
Publicado: (2016)

A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages
por: Bedard, Melissa, et al.
Publicado: (2023)

Desferrioxamine Supports Metabolic Function in Primary Human Macrophages Infected With Mycobacterium tuberculosis
por: Phelan, James Joseph, et al.
Publicado: (2020)

Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids
por: Cambier, C.J., et al.
Publicado: (2013)

An improved synthesis of adefovir and related analogues
por: Jones, David J, et al.
Publicado: (2019)

Validation of online delivery of the Australian Pelvic Floor Questionnaire in an Irish obstetric population
por: O’Leary, Bobby D., et al.
Publicado: (2023)

Canadian Association of Gastroenterology Indicators of Safety Compromise following Colonoscopy in Clinical Practice
por: Borgaonkar, Mark R., et al.
Publicado: (2016)

Enhanced Extracellular Transfer of HLA-DQ Activates CD3(+) Lymphocytes towards Compromised Treg Induction in Celiac Disease
por: Hudec, Michael, et al.
Publicado: (2022)

Acidic Nanoparticles Are Trafficked to Lysosomes and Restore an Acidic Lysosomal pH and Degradative Function to Compromised ARPE-19 Cells
por: Baltazar, Gabriel C., et al.
Publicado: (2012)

A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway
por: O'Leary, Robert, et al.
Publicado: (2011)

mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
por: Pagán, Antonio J., et al.
Publicado: (2022)

A zebrafish model for ocular tuberculosis
por: Takaki, Kevin, et al.
Publicado: (2018)

Coordinated conformational and compositional dynamics drive ribosome translocation
por: Chen, Jin, et al.
Publicado: (2013)

TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit
por: Roca, Francisco J., et al.
Publicado: (2019)

T cell metabolism drives immunity
por: Buck, Michael D., et al.
Publicado: (2015)

Lactate Alters Metabolism in Human Macrophages and Improves Their Ability to Kill Mycobacterium tuberculosis
por: Ó Maoldomhnaigh, Cilian, et al.
Publicado: (2021)

Underdiagnosis of internal anal sphincter trauma following vaginal delivery
por: O'Leary, B. D., et al.
Publicado: (2023)

Linking external stimuli with internal drives: A role for the ventral hippocampus
por: Turner, Victoria S., et al.
Publicado: (2022)

EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer
por: Yang, Lixian, et al.
Publicado: (2019)

Mutated ATP10B increases Parkinson’s disease risk by compromising lysosomal glucosylceramide export
por: Martin, Shaun, et al.
Publicado: (2020)

Inactivation of the three GGA genes in HeLa cells partially compromises lysosomal enzyme sorting
por: Doray, Balraj, et al.
Publicado: (2021)

Redefining the hypotheses driving Parkinson’s diseases research
por: Farrow, Sophie L., et al.
Publicado: (2022)

The efficacy and complications of retropubic tension‐free vaginal tapes after 20 years: A prospective observational study
por: O'Leary, Bobby D., et al.
Publicado: (2022)

Lysosomes
por: Barrnett, Russell J.
Publicado: (1964)

Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits
por: Zembrzycki, Andreas, et al.
Publicado: (2013)

A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy
por: Madigan, Cressida A., et al.
Publicado: (2017)

Clinical utility of using C-reactive protein and procalcitonin as biomarkers for a novel neonatal sepsis diagnostic platform (ASCMicroPlat)
por: McAllister, K, et al.
Publicado: (2012)

Mycobacterium tuberculosis infection induces non-apoptotic cell death of human dendritic cells
por: Ryan, Ruth CM, et al.
Publicado: (2011)

Altered endosomal-lysosomal biogenesis in melanoma
por: Lam, Giang T., et al.
Publicado: (2023)

Intrinsic ecological dynamics drive biodiversity turnover in model metacommunities
por: O’Sullivan, Jacob D., et al.
Publicado: (2021)

Effects of CFTR modulators on serum biomarkers of liver fibrosis in children with cystic fibrosis
por: Levitte, Steven, et al.
Publicado: (2023)

Autophagic-Lysosomal Inhibition Compromises Ubiquitin-Proteasome System Performance in a p62 Dependent Manner in Cardiomyocytes
por: Tian, Zongwen, et al.
Publicado: (2014)

Association of Circulating Tumor DNA With Disease-Free Survival in Breast Cancer: A Systematic Review and Meta-analysis
por: Cullinane, Carolyn, et al.
Publicado: (2020)

Comparison of the effect of lemborexant and other insomnia treatments on driving performance: a systematic review and meta-analysis
por: McElroy, Heather, et al.
Publicado: (2021)

Driving forces behind the evolution of the Aleutian mink disease parvovirus in the context of intensive farming
por: Canuti, Marta, et al.
Publicado: (2016)

A Zebrafish Model of Mycobacterium leprae Granulomatous Infection
por: Madigan, Cressida A, et al.
Publicado: (2017)

On the move, lysosomal CAX drives Ca(2+) transport and motility
por: Lloyd-Evans, Emyr
Publicado: (2016)

Cyber operations: building, defending, and attacking modern computer networks
por: O'Leary, Mike
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d8ua0j40ba48jcp9mpmbgea21g